Graphene Nanoplatelets Render Poly(3-Hydroxybutyrate) a Suitable Scaffold to Promote Neuronal Network Development

The use of composite biomaterials as innovative bio-friendly neuronal interfaces has been poorly developed so far. Smart strategies to target neuro-pathologies are currently exploiting the mixed and complementary characteristics materials better design future neural interfaces. Here we present a polymer-based scaffold that rendered suitable for primary neurons by embedding graphene nanoplatelets (GnP). In particular, growth, network formation, functionality on poly(3-hydroxybutyrate) [P(3HB)] polymer supports functionalized with various concentrations GnP were explored. After growing cortical onto 14 days, all specimens found be biocompatible, revealing physiological growth maturation network. When was investigated whole patch-clamp measurements, pure P(3HB) led changes in action potential waveform reduction firing frequency, resulting decreased excitability. However, addition matrix restored electrophysiological parameters values. Interestingly, low concentration able promote activity at level injected current. results indicate P(3HB)/GnP composites show great electrical interfacing eventually central nervous system disorders.